CryoEM Structure of Human Platelet Integrin αIIbβ3
Research Overview:
- Context:
- Investigating the CryoEM structure of the full-length Human Platelet Integrin αIIbβ3.
- Relevance:
- Implications for myocardial infarction, stroke, thrombosis, oncology, and inflammation.
- Timeline:
- Progress spanned over 20 years (2002 - 2023).
Researchers:
- Authors:
- Brian D. Adair and Mark Yeager.
- Affiliations:
- The Scripps Research Institute, Dept. of Molecular Biology.
- Scripps Clinic, Division of Cardiovascular Disease.
Publication Details:
- Source:
- Proc. Natl. Acad. Sci. 99, 14059-14064 (2002).
- Key Finding:
- Transmembrane signaling spans 250 Å.
Explore two decades of groundbreaking research by Brian D. Adair and Mark Yeager at The Scripps Research Institute, delving into the CryoEM structure of Human Platelet Integrin αIIbβ3 and its profound implications across various medical domains.
Membrane mimetic: detergent&8203; octyl-β-D-glucopyranoside micelle&8203;
High-Resolution Molecular Structure of Integrin
Researchers:
- Contributors:
- Brian D. Adair, Jian-Ping Xiong, Mark Yeager, M. Amin Arnaout.
Affiliations:
- 1. Massachusetts General Hospital, Harvard Medical School
- 2. The Frost Institute for Chemistry and Molecular Science
Published Work:
- Source:
- Nature Commun. 14:4168 (July 13, 2023).
Key Achievement:
- Milestone:
- Unveiling the first high-resolution molecular structure of the full-length integrin, featuring a groundbreaking visualization of the transmembrane α-helices.
Explore the collaborative research efforts of Brian D. Adair, Jian-Ping Xiong, Mark Yeager, and M. Amin Arnaout at renowned institutions, bringing forth a significant advancement in molecular structural analysis published in Nature Communications.
Membrane mimetic:&8203;
- SMALP (styrene-maleic acid lipid particles),&8203;which solubilizes membrane patches with the native lipids&8203;
